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pentobarbital will lessen the level or impact of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.Barbiturates can induce hepatic microsomal enzymes causing increased metabolism and lessened anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); sufferers sta

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